The Science Behind NeuroVibe's Brain Fuel Formula
Alpha-GPC
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 600mg of Alpha-GPC.
Origin & History:
Alpha-GPC is derived from soy or sunflower lecithin, Alpha-GPC is a natural choline compound.
First studied in the 1980s for cognitive enhancement and later recognised for its role in acetylcholine synthesis, a key neurotransmitter for memory and learning.
Key Benefits:
Supports cognitive function, memory and focus by increasing acetylcholine levels.
Time To Effects:
Some users report acute effects within 1-2 hours for focus, but consistent use 2 weeks or more maybe needed for long-term cognitive benefits.
Studies:
Can increase motivation to learn as shown by “Tamura Y, Takata K, Matsubara K, Kataoka Y. Alpha-Glycerylphosphorylcholine Increases
Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study. Nutrients. 2021 Jun 18;13(6):2091. doi:
10.3390/nu13062091. PMID: 34207484; PMCID: PMC8235064.”
Can increase cognitive performance as shown by “Kerksick CM. Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance
in Healthy Men. Nutrients. 2024 Dec 9;16(23):4240. doi: 10.3390/nu16234240.
PMID: 39683633; PMCID: PMC11644786.”
NAD+
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 500 mg of NAD+.
Origin & History:
Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in all living cells.
Discovered in 1906, its role in cellular energy and DNA repair became clear in the mid-20th century.
Key Benefits:
Research shows NAD+ supports mitochondrial function, energy metabolism, and may slow cellular aging.
NAD+ may improve mental clarity and reduce fatigue by enhancing ATP production.
Time To Effects:
Some feel an acute boost within hours hours for energy, but long term benefits take weeks or months for cellular repair and anti-aging effects.
Studies:
“Has been identified as a key therapeutic target that can positively impact many of the hallmarks of cellular aging” Conlon NJ. The Role of NAD+ in Regenerative Medicine. Plast Reconstr Surg. 2022 Oct 1;150(4 Suppl):41S-48S. doi: 10.1097/PRS.0000000000009673. Epub 2021 Sep 28. PMID: 36170435; PMCID: PMC9512238.
“NAD+ improves cognitive function and reduces neuroinflammation” Zhao, Y., Zhang, J., Zheng, Y. et al. NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. J Neuroinflammation 18,
207 (2021). https://doi.org/10.1186/s12974-021-02250-8
DMAE Bitartrate
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 300 mg of DMAE Bitartrate.
Origin & History:
Dimethylaminoethanol (DMAE) was first studied in the 1950s for cognitive effects.
Popularised as a nootropic for its acetylcholine boosting properties.
Key Benefits:
Supports focus and mood by potentially increasing acetylcholine and dopamine.
Some studies suggest it may improve memory and reduce brain fog.
Time To Effects:
For alertness some find the acute effects start within hours, for optimal benefits it may take 1-2 weeks of consistent use.
Studies:
“Therefore the vitamine-mineral drug combination containing DMAE can be interpreted to induce a psychophysiological state of better feeling of wellbeing” Dimpfel W, Wedekind W, Keplinger I. Efficacy of
dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. Eur J Med Res. 2003 May
30;8(5):183-91. PMID: 12844472.
Rhodiola Rosea
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 600 mg of Rhodiola Rosea which include 15 mg of salidroside.
Origin & History:
A perennial flowering plant and traditional adaptogen from Arctic and mountainous regions used in Scandinavian and Russian medicine for centuries.
Soviet research in the 1960s validated its anti-fatigue and stress resistance properties.
Key Benefits:
Clinically shown to reduce mental fatigue and improve endurance. Supports stress adaptation via cortisol modulation.
Time To Effects:
Acute effects for fatigue reduction can be felt within hours, full adaptogenic benefits may take over two weeks of consistent use.
Studies:
“Overall, in accordance with its aim, the results presented in this review provide an encouraging basis for the clinical efficacy of R. rosea preparations in managing various aspects of stress-induced conditions.” Ivanova Stojcheva E, Quintela JC. The Effectiveness of Rhodiola rosea L. Preparations in Alleviating Various Aspects of Life-Stress Symptoms and Stress-Induced Conditions-Encouraging Clinical Evidence. Molecules. 2022 Jun 17;27(12):3902. doi: 10.3390/molecules27123902. PMID:
35745023; PMCID: PMC9228580.
“In conclusion, the findings suggested that R. rosea L. can improve learning and memory function.” AUTHOR=Ma Gou-ping , Zheng Qun , Xu Meng-bei , Zhou Xiao-li , Lu Lin , Li Zuo-xiao , Zheng Guo-Qing TITLE=Rhodiola
rosea L. Improves Learning and Memory Function: Preclinical Evidence and
Possible Mechanisms JOURNAL=Frontiers in Pharmacology VOLUME=Volume 9 – 2018 YEAR=2018
URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2018.01415
DOI=10.3389/fphar.2018.01415 ISSN=1663-9812
Ginkgo Biloba
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 140 mg of Ginkgo Biloba which includes 24% Flavanoids and 6% Tarpenoids.
Origin & History:
One of the oldest living tree species, used in Chinese medicine for millennia.
German researchers in the 1960s isolated its active compounds for cognitive benefits.
Key Benefits:
Studies suggest it improves blood flow to the brain, aiding memory and executive function. Ginkgo Biloba may also protect against oxidative stress.
Time To Effect:
Effects build over 4-6 week of consistent use, acute benefits are minimal.
Studies:
"The results showed that 120 mg of Ginkgo engendered a significant improvement on the ‘quality of memory" Modulation of cognitive performance following single doses of 120 mg Ginkgo biloba extract administered to healthy young volunteers” David O. Kennedy, Pillipa A.
Jackson, Crystal F. Haskell, Andrew B.
Scholey 2007 https://doi.org/10.1002/hup.885
“it appeared to stabilize and improve the cognitive performance as well as social functioning of dementia patients for six months to 1 year.” Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA. 1997 Oct 22-29;278(16):1327-32.
Bacopa Monnieri
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 240 mg of Bacopa Monnieri of which 50% is Bacosides.
Origin & History:
A staple in Ayurvedic medicine for 3,000+ years, first scientifically studied in the 1960s. Bacopa Monnieri is a perennial herb native mainly to wetlands and marshy regions of India and Southeast Asia.
Key Benefits:
Clinical trials show it enhances memory retention and learning by promoting neuron communication. Studies show Bacopa Monnieri may reduce anxiety over time.
Time To Effect:
Requires 4-8 weeks of consistent use to show benefits.
Studies:
“Thirty-six subjects from placebo group and 38 subjects from BME group completed the study. BME group showed significant improvements on
both memory (verbal short-term memory, spatial short-term memory, working memory, visuospatial working memory, and episodic memory) and cognition skills (concentration, alertness, reasoning, and mental flexibility) over placebo from
baseline to Day 84” Citation: Eraiah MM, Shekhar HC, Joshua L, Thomas JV (2024) Effect of Bacopa monnieri Extract on Memory and Cognitive Skills in Adult Humans: A Randomized, Double-Blind, Placebo-Controlled Study. J Psychiatry Cogn
Behav 8: 168. https://doi.org/10.29011/2574-7762.000068
“Controlling for baseline cognitive deficit using the Blessed Orientation-Memory-Concentration test, Bacopa participants had enhanced AVLT delayed word recall memory scores relative to placebo. Stroop results were
similarly significant, with the Bacopa group improving and the placebo group
unchanged.” Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. J Altern Complement Med. 2008 Jul;14(6):707-13. doi: 10.1089/acm.2008.0018. PMID: 18611150; PMCID: PMC3153866.
L-Theanine
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 400 mg of L-Theanine.
Origin & History:
An amino acid primarily found in green tea leaves, scientifically discovered in 1949. However its roots in providing relaxation date back much further to the 8th Century where in China and Japan tea ceremonies prized green tea for its ability to induce relaxed alertness.
It is also noted to have been used by Zen monks to stay calm yet focused during meditation.
Key Benefits:
Research confirms it reduces stress and anxiety by increasing alpha brain waves.
Time To Effect:
L-Theanine works within 30-60 minutes for relaxation; long-term use may support sustained stress resilience.
Studies:
“Our findings suggest that L-theanine has the potential to promote mental health in the general population with stress-related ailments and cognitive impairments.” Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, Ozeki M, Kunugi H. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. PMID: 31623400; PMCID: PMC6836118.
“Results evidently demonstrated that L-theanine clearly has a pronounced effect on attention performance and reaction time response in normal healthy subjects prone to have high anxiety.” Akiko Higashiyama, Hla Hla Htay, Makoto Ozeki, Lekh R. Juneja, Mahendra P. Kapoor, Effects of l-theanine on attention and reaction time response, Journal of Functional Foods, Volume 3, Issue 3, 2011, Pages 171-178, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2011.03.009.
Piperine
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 10 mg of Piperine.
Origin & History:
Derived from black pepper, used in Ayurveda medicine to enhance bio-availability, Piperine has been studied since the 1970s for its inhibition of drug-metabolizing enzymes.
Key Benefits:
Research shows it can help the absorption of other compounds into the body such as Bacopa Monnieri.
Time To Effects:
Piperine works immediately to enhance bio-availability of co-ingested nutrients.
Studies:
“Piperine displays numerous pharmacological effects such as antiproliferative, antitumor, antiangiogenesis, antioxidant, antidiabetic, anti-obesity, cardioprotective, antimicrobial, antiaging, and immunomodulatory effects in various in vitro and in vivo experimental trials.” Haq IU, Imran M, Nadeem M, Tufail T, Gondal TA, Mubarak MS. Piperine: A review of its biological effects. Phytother Res. 2021 Feb;35(2):680-700. doi: 10.1002/ptr.6855. Epub 2020 Sep 14. PMID: 32929825.
Zinc
Amount Per Serving:
A 2 gummy serving of NeuroVibe brain fuel contains 10 mg of Zinc.
Origin & History:
An essential trace mineral, used medically since ancient Egypt. Recognized in the 20th century for immune and neurological functions.
Key Benefits:
Research indicates it supports immune function, neurotransmitter production and synaptic plasticity.
Zinc may improve mood and cognitive performance in Zinc deficient individuals.
Time To Effects:
Deficiency correction takes time but acute benefits such as immune support may occur sooner.
Studies:
“Zinc is a multipurpose trace element for the human body, as it plays a crucial part in various physiological processes, such as cell growth and development, metabolism, cognitive, reproductive, and immune system function. Its significance in human health is widely acknowledged” Kiouri DP, Tsoupra E, Peana M, Perlepes SP, Stefanidou ME, Chasapis CT. Multifunctional role of zinc in human health: an update. EXCLI J. 2023 Aug 4;22:809-827. doi: 10.17179/excli2023-6335. PMID: 37780941; PMCID: PMC10539547.